Discontinuous Conduction in Mouse Bundle Branches Is Caused by Bundle-Branch Architecture

Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture.

BACKGROUND Recordings of the electrical activity of mouse bundle branches (BBs) suggest reduced conduction velocity (CV) in the midseptal compared with the proximal part of the BB. The present study was performed to elucidate the mechanism responsible for this slowing of conduction. METHODS AND RESULTS Hearts of 16 mice were isolated and Langendorff perfused. After the right and left ventricu...

Deceleration-dependent left bundle branch block: a spectrum of bundle branch conduction delay.

The authors thank Dr. N.H.G. Holford, assistant professor of Medicine, Pharmacy and Pharmacological Chemistry, University of California, San Francisco, for his constructive review of this manuscript, and Dr. S. Lee, Director, Hematology Department, Cedars-Sinai Medical Center. In addition, we express our gratitude to Joye Nunn for secretarial assistance, to Lance Laforteza for graphics, and to ...

His Bundle electrogram in bundle-branch block.

SUMMARY Because a great majority of patients with chronic complete heart block have bilateral bundle-branch lesions, it becomes important to recognize earlier degrees of bilateral bundle-branch block. The H-V interval in the His bundle electrogram during unilateral bundle-branch block reflects the conduction primarily through the contralateral bundle branch, and thus the His bundle electrogram ...

Longitudinal dissociation in the His bundle. Bundle branch block due to asynchronous conduction within the His bundle in man.

Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40.

BACKGROUND Connexin (Cx)40 and Cx45 are the major protein subunits of gap junction channels in the conduction system of mammals. To determine the role of Cx40, we correlated cardiac activation with Connexin distribution in normal and Cx40-deficient mice hearts. METHODS AND RESULTS Epicardial and septal activation was recorded in Langendorff-perfused adult mice hearts with a 247-point compound...